Our focused compound libraries comprise collections of compounds with in silico predicted affinity to a target protein or predicted biological activity. In order to design focused
libraries ArZa Biosciences applies different computational methods used in structure-based drug design. More than 300 target-focused libraries are now available.
Approach Used
Our proprietary method for receptor-based virtual screening of compounds includes powerful combination of drug-likeness filtering, molecular docking, re-scoring, key intermolecular hydrogen bond detection and, finally, visual inspection of ligand receptor complexes. The approach used to design ligand-based focused libraries exploits the SAR analysis. It compares structures of new compounds with structures of well-known biologically active substances (“training set”). The training set we use consists of about 200,000 of biologically active compounds.
Variety of the Libraries
ArZa’s approach to designing these libraries is to focus our attention on the targets from different protein families: epigenetic targets, PPI, GPCR's, protein kinases, ion channels, proteases and others. Our company also offers focused libraries of compounds with certain biological activity: anticancer, antiviral, analgesic, antibacterial etc. All compounds are for prompt delivery. For further information on these types of libraries please contact us.
General
- GPCR library
- Ion Channels
- Kinase docking
- Kinase similarity
- Kinase Targeted Screening
- Nuclear Receptors
- Protease Targeted Libraries
- Aquaporins Targeted Libraries
- ATPase Targeted Libraries
- Natural Product-like Compounds Library
- Epigenetic Targeted Libraries
- Polymerase Targeted Library
- Helicase Targeted Library
- Phosphatase Targeted Library
- CYP Inhibitors Library
- PPI Focused Libraries (Ligand-based)
- PPI Targeted Libraries (Receptor-based)
- Protease Targeted LASSO Screening Libraries
- Deubiquitinase Targeted Libraries
Sharp Focused
- Human Fibroblast Growth Factor Receptor 1 Tyrosine Kinase (FGFR1K) focused library
- 3-Phosphoinositide-dependent kinase-1 (PDK-1) focused library
- Phosphatidylinositol 3-kinase (PI3K) focused library
- cAMP dependent protein kinase (PKA) focused library
- Human Janus Kinase (Jak) Focused Libraries
- Rho-associated Protein Kinases (ROCK) Focused Libraries
- ERK5 Kinase Focused Library
- Aurora A Kinase Focused Library
- Aurora B Kinase Focused Library
- Cyclin-dependent Kinase 2 (CDK2) Focused Library
- P38 Mitogen-Activated Protein (MAP) Kinase Focused Library
- Vascular Endothelial Growth Factor Receptor Kinase 2 (VGFR-2) Focused Library
- c-Met Kinase (Hepatocyte Growth Factor Receptor (HGFR)) Focused Library
- Phosphodiesterase 10 (PDE10) Focused Library
Activity Targeted
- Antibacterial
- Anticancer
- Antiviral
- CNS Targeted Library
- Antiprotozoa
- Antituberculosis
- Hepatitis C Virus (HCV) Targeted Library
Other
- AgroChemical Libraries
- Bioactive Compounds
- Glutamate Receptors
- Covalent Inhibitors Library
- Cysteine Focused Covalent Inhibitors
- Task Specific Calixarenes
- Serine Focused Covalent Inhibitors
Fragment Libraries
- General Fragment Library
- Superior Fragment Library
- Tangible Fragments Library
- Fluorinated Fragment Library
- Bromine-based Fragment Library
- Fsp3-enriched Fragments Library
- Fragment Library with Experimental Solubility Data
- PPI Fragments Library
- 3D Fragment Library
- Covalent Fragment Library
- Advanced Tangible Fragments
- Fluorine Fragment Cocktails
- Natural Product-like Fragment Library