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UPLC–MS/MS analysis of aristolochic acid I and aristolactam I in multiple matrices for exposure assessment

Anal. Methods, 2025, Accepted Manuscript
DOI: 10.1039/D5AY01417D, Paper

Yu-Ting Ding, Zehua Liu, Jun Zhang, Qiang Wei, Yun Liu
Aristolochic acid I (AA-I) and its metabolite aristolactam I (AL-I) are nephrotoxic and carcinogenic compounds derived from Aristolochia species, which have been widely used in traditional herbal medicines. While previous...
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An ultrasensitive sandwich-type electrochemical immunosensor for PSA detection: employing layer-by-layer self-assembly with poly(thionine)/carbon nanotube multilayers as electron mediators and hemin-functionalized PEI/SiO2 nanoparticles as signal amplifiers

Anal. Methods, 2025, Accepted Manuscript
DOI: 10.1039/D5AY01330E, Paper

Zheng Chang, Zhenyuan Duan, Junpeng Li, Xiangze Meng
In this study, hemin-functionalized polyethyleneimine/silica nanoparticles (hemin/PEI/SiO2 NPs) served as an electrochemical label for ultrasensitive detection of prostate-specific antigen (PSA), a clinically important prostate cancer biomarker. A poly(thionine)/carbon nanotube (PTh/CNTs)...
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Is it possible to distinguish virgin versus pyrolytic recycled styrene by determining the intramolecular 13C distribution?

Anal. Methods, 2025, Advance Article
DOI: 10.1039/D5AY01257K, Communication

Maxime Julien, Carlos Andrés Rincón Mejía, Mathilde Grand, Anne-Marie Schiphorst, Estelle Martineau, Serge Akoka, Thibaud Herbst, Gérald S. Remaud
The newly observed divergence in ¹³C intramolecular isotope profiles between virgin and pyrolytically recycled styrene, purified by distillation, introduces a novel approach for tracing styrene’s provenance through position-specific isotope analysis.
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An intelligent diagnostic algorithm for Raman spectroscopy of gastrointestinal cancer based on component modeling

Anal. Methods, 2025, Accepted Manuscript
DOI: 10.1039/D5AY01178G, Paper

Mingkun Wang, Juan Li, Wenbo Mo, Daojian Qi, Shuang Ni, Feng Tang, Xinming Wang, Chun Qing, Minjie Zhou
Background: Early diagnosis of gastrointestinal (GI) cancer is crucial for patient prognosis, yet conventional methods suffer from invasiveness and insufficient molecular sensitivity. Raman spectroscopy offers non-invasive molecular fingerprinting, but spectral...
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Leveraging R for advanced interpretation of LDI-TOF mass spectra: a computational approach

Anal. Methods, 2025, Advance Article
DOI: 10.1039/D5AY01246E, Technical Note

Open Access

&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Lubomír Prokeš, Lukáš Pečinka
A novel R-based workflow enables advanced modeling of complex isotopic distributions in LDI-TOF mass spectra, addressing limitations conventional software.
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Demonstrating the application of a liquid chromatography-mass spectrometry method for the determination of phthalate diesters in complex solid and liquid environmental samples

Anal. Methods, 2025, Advance Article
DOI: 10.1039/D5AY01057H, Paper

Open Access

&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Fiona Regan, Catherine Allen, Jenny Lawler
A sensitive contaminantion-controled LC-MS/MS workflow quantifies 11 phthalate diesters in environmental samples with sub ng L⁻¹ limits.
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Designing a locally produced DENV-1 nucleic acid diagnostic for low resource regions with endemic disease

Anal. Methods, 2025, Advance Article
DOI: 10.1039/D5AY00889A, Paper

Open Access

&nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Adam Roberts, Dushanth Seevaratnam, Ferguie B. Solis, Maria Rhona G. Bergantin, Dharmatov Rahula B. Albano, Fortunato B. Sevilla, Elizabeth A. H. Hall
Recombinant local-production of innovative silica bound RT-LAMP enzymes, extends shelf-life for use in endemic Dengue diagnostic, using novel DENV-1 primer-set.
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Carvedilol microemulsion-loaded oleogel: development and validation via an HPLC method, identification of three degradation products, and toxicity prediction

Anal. Methods, 2025, Advance Article
DOI: 10.1039/D5AY01393C, Paper

Ibtihal Abuhamdeh, Rania Hamed, Rima Hajjo, Nancy Sowan, Kamal Sweidan
An HPLC method for a carvedilol microemulsion-loaded oleogel was validated; the degradants were identified by LC/MS with proposed molecular structures.
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A synergistic polyimide-silver nanowire interface enables simultaneous electrochemical detection of nitrophenol isomers

Anal. Methods, 2025, Advance Article
DOI: 10.1039/D5AY01293G, Paper

Zuhang Ding, Jianzheng Wang, Jing Jin, Minjie Guo, Qinran Li, Zhi Fan, Jin Zhao
The research describes an electrochemical sensor based on a polyimide-silver nanowire composite that is used to modify a glassy carbon electrode for the simultaneous detection of multiple nitrophenol isomers with high performance.
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A highly sensitive electrochemiluminescence immunosensor based on Ru(bpy)32+/PAMG composite carriers and Au–Fc-MOF quenching systems for ultra-trace detection of carcinoembryonic antigen

Anal. Methods, 2025, Advance Article
DOI: 10.1039/D5AY01289A, Paper

Baohan Wen, Haoyi Ren, Wenjing Lai, Min Wang, Mingzhe Jiang, Yingying Cheng, Yige Li, Chenglin Hong, Yu Qi
A sensitive ECL technique for CEA detection is developed, using Ru(bpy)₃²⁺ as an emitter, Au–Fc-MOF as a quencher/label, and K₂S₂O₈ as a co-reactant; the immunosensor shows linearity and a low detection limit, aiding early cancer diagnosis.
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