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Rapid and sensitive detection of circulating tumor DNA via CRISPR/Cas12a-based catalytic hairpin assembly

Anal. Methods, 2025, Accepted Manuscript
DOI: 10.1039/D5AY01624J, Paper

Songbai Tian Tian, lingzi yao, Feng Gong, Ying Li, Yujie Zhao, yixia yang
Cancer is one of the major diseases that endanger human health. Circulating tumor DNA (ctDNA) is an ideal biomarker for real-time monitoring of cancer. In the present work, a rapid...
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Adhesive tape for spatially resolved and sensitive detection of lead in dust using XRF

Anal. Methods, 2025, Accepted Manuscript
DOI: 10.1039/D5AY01275A, Paper

Open Access

&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.

Ornella Joseph, Vikrant Jandev, Zhutian Zhang, Darbie Kwon, Brighten Cho, Devena Sammanasu, Alyssa Wicks, Marya Lieberman
A method for rapidly and quantitatively measuring lead (Pb) in dust has been developed. While numerous wipes were tested, an adhesive wipe in the form of a portion of Painter’s...
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Stability-indicating study of Iguratimod: Isolation and characterization of potential degradant using Preparative HPLC-MS, LC-HRMS, and NMR techniques

Anal. Methods, 2025, Accepted Manuscript
DOI: 10.1039/D5AY01432H, Paper

Pratik Gore, Dnyaneshwar Maykar, Anima maity, Pramod Kumar
Iguratimod (IGRD), a disease-modifying antirheumatic drug, emerged as a promising therapeutic agent due to its potent immunomodulatory effect in autoimmune diseases. In this study, a green and selective stability-indicating RP-HPLC-DAD...
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Diagnostic performance of thioflavin T in one-step RT-PCR for detection of a viral RNA

Anal. Methods, 2025, 17,9244-9253
DOI: 10.1039/D5AY01327E, Paper

Reyhaneh Tavakoli-Koopaei, Fatemeh Javadi-Zarnaghi, Fariba Dehghanian, Reza Mohammadi Manesh
The TQsyn RT-PCR is a new fluorimetric method for SARS-CoV-2 detection. This method is based on the incorporation of thioflavin into the synthesized G-quadruplex structure during PCR amplification.
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Ion association reactions: theoretical and experimental perspectives for quantification of pollutants

Anal. Methods, 2025, 17,9062-9092
DOI: 10.1039/D5AY01102G, Critical Review

Subhadeep Biswas, Anjali Pal, Sohini Sarkar, Tarasankar Pal
Ionistation association varies with the solvent dielectric constant, added salt, temperature and pressure for discrete electrostatic binding between bulky ions.
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Uncertainty evaluation of Cd concentration in sphalerite by ICP-OES: a comparative study between GUM and Monte Carlo methods

Anal. Methods, 2025, 17,9234-9243
DOI: 10.1039/D5AY01492A, Paper

Chenglin Li, Lin Xu, Pan Wang, Dandan Tang, Jianbing Xu, Hai Wang, Yizhan Wang, Shuilong Wang, Wenning Lu
WLS-MCM synergy enhances the precision of Cd determination in sphalerite by ICP-OES.
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2D-fluorescence sensor array for protein identification under various osmolyte and pH conditions

Anal. Methods, 2025, 17,9118-9122
DOI: 10.1039/D5AY01390A, Paper

Yue Wang, Hui Ju, Peng Yan
A simple 2D-fluorescence sensor array was developed using variations in pH and osmolyte conditions to generate fingerprint-like patterns from differential protein–quantum dots interactions, enabling protein discrimination.
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A water-soluble and lysosome-targeted pH fluorescent probe for analytical monitoring of cellular oxidative stress and in vivo non-invasive imaging of alcoholic gastritis in mice

Anal. Methods, 2025, 17,9208-9215
DOI: 10.1039/D5AY01472G, Paper

Yukun Zhang, Lie Li, Ruiyuan Liu, Jinqing Qu
As a key acidic organelle, the pH homeostasis of lysosomes is critical for cellular functions.
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Estimating concentrations of atmospheric pollutants in mixed gases based on deep convolutional network with time series decomposition

Anal. Methods, 2025, 17,9262-9273
DOI: 10.1039/D5AY01235J, Paper

Xiaolong Zheng, Jiangnan Xie, Lili Li, Weipeng Xuan, Hui Zheng, Zhihua Ying
This paper presents a multi-sensor deep learning framework that utilizes time-series decomposition for mixed gas concentration estimation and enhances its precision through data augmentation, enabling high-accuracy monitoring of mixed gases.
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Red blood cells as probes for determining free QS21 in liposomal adjuvant formulations to support product safety and stability

Anal. Methods, 2025, 17,9162-9170
DOI: 10.1039/D5AY00854A, Paper

Open Access

&nbsp This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Essie Komla, Cierra Rochelle, Adrian Carreon, Oscar B. Torres, Gary R. Matyas, Erwin G. Abucayon
Analytical method development is critical to establishing and supporting drug product quality.
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